Epredia™ Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-3 Mouse Monoclonal Antibody, 200μg/mL, BSA and azide

Ensure accurate, reproducible results in immunofluorescence and immunoprecipitation experiments.

Supplier:  Epredia™ MS1248P1

Catalog No. MS1248P1

Description

CFTR (cystic fibrosis transmembrane conductance regulator) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

Host Species: Mouse

Clone: L12B4

Isotype: IgG1

Species Reactivity: Human, Mouse and Rat. Others not known.

Epitope: aa 386-412

Immunogen: Recombinant protein encoding NBF1 domain of human CFTR

Molecular Weight: 165-170 kDa

Positive Control: Pancreas

Cellular Localization: Membrane

Recommended for:

• Western Blotting (Not verified)
• Immunofluorescence
• Immunoprecipitation

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-3
• Classification: Monoclonal
• Concentration: 200μg/mL
• Host Species: Mouse
• Quantity: 500 μL
• Primary or Secondary: Primary
• Form: Concentrated

• Applications: Immunofluorescence, Immunoprecipitation
• Clone: L12B4
• Conjugate: Unconjugated
• Immunogen: Recombinant protein encoding NBF1 domain of human CFTR
• Regulatory Status: RUO
• Target Species: Human, Mouse, Rat
• Isotype: IgG1