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Thermo Scientific™ Lab Vision™ Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-4, Mouse Monoclonal Antibody

Obtain accurate, reproducible results in immunohistochemistry, immunofluorescence and immunoprecipitation experiments.

Manufacturer:  Thermo Scientific™ MS1249P1

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Catalog No. MS1249P1


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Description

Description

Obtain accurate, reproducible results in immunohistochemistry, immunofluorescence and immunoprecipitation experiments with Thermo Scientific™ Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-4, Mouse Monoclonal Antibody.

CFTR (cystic fibrosis transmembrane conductance regulator) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

Host Species: Mouse

Clone: M3A7

Isotype: IgG1

Species Reactivity: Human, Mouse and Rat. Others not known.

Epitope: aa 1370-1380

Immunogen: Recombinant protein encoding NBF2 domain of human CFTR

Molecular Weight: 165-170 kDa

Positive Control: Pancreas

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not verified)
  • Immunofluorescence
  • Immunoprecipitation

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

Cystic Fibrosis Transmembrane Regulator (CFTR) Ab-4
Monoclonal
200μg/mL
Purified Ab with BSA and Azide
Murine
IgG1
RUO
Primary
Human, Murine, Rat
Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
M3A7
Unconjugated
Concentrated
Recombinant protein encoding NBF2 domain of human CFTR
500μL
Primary
Monoclonal
SDS
Documents
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