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Cytochrome C Mouse anti-Human, Clone: 2G8, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen BMS195

Catalog No. 50-178-53


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Description

Description

Description: A second major function for cytochrome c is its role as an intermediate in apoptosis, both through its association with inositol-3-phosphate receptor (IP3 receptor) which acts as an ER calcium release channel, and its association with apoptotic protease activating factor 1 (Apaf-1), resulting in the formation of the apoptosome protein complex which then recruits and activates pro-caspase 9 (Apaf-3). This antibody recognises cytochrome c, originally termed Apaf-2, an evolutionarily conserved protein which acts as an essential mitochondrial electron carrier between respirable substrates and oxygen, during aerobic energy production. Clone 2G8 is reported to block the role of cytochrome c as a co-factor in the activation of caspase 9. Applications Tested: ELISA, Flow Cytometry (Intracellular Staining), Functional Studies (Blocking).

Cytochrome C is an electron transporting protein that resides within the intermembrane space of the mitochondria, where it plays a critical role in oxidative phosphorylation and the production of cellular ATP. Release of cytochrome C from the mitochondria to the cytosol is triggered by apoptotic stimuli. In the cytoplasm, the cytochrome C binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Cytosolic cytochrome C functions in the activation of caspase 3, an ICE family molecule that is a key effector of apoptosis.
Specifications

Specifications

Cytochrome c
Monoclonal
1 mg/mL
PBS with no preservative
P99999
Cyt C
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
ELISA, Flow Cytometry, Functional Assay
2G8
Unconjugated
CYCS
Liquid
CYCS
IgG1, kappa
100 μg
-20°C
Primary
54205
SDS
Documents
Product Certifications
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