Cytokeratin 7/17 Monoclonal Antibody (C-46), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA119045

Catalog No. 01-675-018

Description

This antibody will not cross-react with mouse, rat or rabbit.

Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between ∽40 kDa and ∽68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

Specifications

• Antigen: Cytokeratin 7/17
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene Accession No.: A1L595, P08729, Q04695, Q29S21
• Gene Symbols: KRT17, KRT7, LOC100626483
• Immunogen: Cytoskeleton preparation of HeLa human cervix carcinoma cell line.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Bovine, Human, Pig
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: C-46
• Conjugate: Unconjugated
• Gene: KRT7
• Gene Alias: 39.1; CK-17; CK7; CK-7; cytokeratin 7; cytokeratin-17; Cytokeratin-7; K17; K2C7; K7; keratin 14; keratin 17; keratin 17, type I; keratin 7; keratin 7, type II; keratin, 55K type II cytoskeletal; keratin, simple epithelial type I, K7; keratin, type I cytoskeletal 17; Keratin, type II cytoskeletal 7; keratin-17; Keratin-7; keratin-associated protein 7-1; KRT14; KRT17; KRT7; LOC100626483; LOC100737113; PC; PC2; PCHC1; sarcolectin; SCL; similar to keratin 7; type II mesothelial keratin K7; type-II keratin Kb7
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100626483, 100626722, 281889, 3855, 3872, 535697
• Content And Storage: 4° C, do not freeze
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov