Invitrogen™ Cytokeratin Pan Type II Monoclonal Antibody (AE3)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA15762

Catalog No. 01-675-181

Description

MA1-5762 reacts with all basic (type II) human keratins in human samples, including K1, K2, K3, K4, K5, K6, K7 and K8. MA1-5762 has been successfully used in Western blot, immunohistochemistry and electron microscopy procedures. The MA1-5762 immunogen is human epidermal keratins.

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

Specifications

• Antigen: Cytokeratin Pan Type II
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: O93532, P02538, P04104, P04264, P05786, P05787, P07744, P08729, P11679, P12035, P13647, P19013, P35908, P50446, Q01546, Q10758, Q148H8, Q14CN4, Q29426, Q29S21, Q3TTY5, Q3UV17, Q4FZU2, Q5XQN5, Q6IG00, Q6IG02, Q6IG04, Q6IG12, Q6IME9, Q6IMF3, Q6P6Q2, Q922U2, Q9DCV7
• Gene Symbols: KRT1, KRT2, KRT3, KRT4, KRT5, Krt6a, KRT7, KRT72, KRT76, KRT8
• Immunogen: Human epidermal keratins from P3 x 63 Ag8 cells.
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Rabbit, Monkey, Bovine, Pig, Chicken
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: AE3
• Conjugate: Unconjugated
• Gene: KRT7
• Gene Alias: 2310016L08Rik; 3300001P10Rik; 57kd keratin; 57kDa keratin; 58 kda cytokeratin; 60-kDa keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; AA960620; AI507495; AL022697; alpha keratin; AU019895; AW108092; AW146334; BB005427; Card2; CK 2e; CK1; CK-1; CK-2e; CK3; CK-3; CK4; CK-4; CK5; CK-5; CK6A; CK-6A; CK6C; CK-6C; CK6D; CK-6D; CK-6E; CK7; CK-7; CK-72; CK8; CK-8; CYK4; CYK8; CYKER; cytokeratin 1; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; cytokeratin 7; cytokeratin 8; cytokeratin 8 (370 AA); cytokeratin endo A; Cytokeratin otokeratin; cytokeratin type II, component Ib/c; cytokeratin type II, component III; Cytokeratin-1; Cytokeratin-2e; cytokeratin-3; Cytokeratin-4; cytokeratin-5; Cytokeratin-6A; cytokeratin-6C; Cytokeratin-6D; cytokeratin-6E; cytokeratin-7; Cytokeratin-72; cytokeratin-8; Cytokeratin-A; cytoskeletal 57 kDa keratin; D15Wsu77e; DDD; DDD1; ear specific cytokeratin; EBS2; EGK_03684; EGK_03685; EHK; EHK1; EndoA; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolytic hyperkeratosis 1; epithelial keratin 1; epithelial keratin 2e; Epithelial keratin-1; Epithelial keratin-2e; EPPK; Hair alpha protein; Hom s 5; K1; K2C7; K2C8; K2E; K3; K3 keratin; K4; K5; K6A; K6a keratin; K6C; K6D; K6irs; K6IRS2; K7; K72; K8; kamp-keratin derived antimicrobial peptide; Kb1; Kb2; Kb35; Kb4; Kb7; KDAMP; KER1; Ker2; KERA; keratin; keratin 1; keratin 1 (epidermolytic hyperkeratosis); keratin 1, type II; keratin 2; keratin 2 (epidermal ichthyosis bullosa of Siemens); keratin 2 epidermis; keratin 2, type II; keratin 2A; keratin 2A (epidermal ichthyosis bullosa of Siemens); keratin 3; keratin 3, type II; keratin 4; keratin 4, type II; keratin 5; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6 alpha; keratin 6, inner root sheath, 2; keratin 6A; keratin 6A, , type II; keratin 6A, type II; keratin 7; keratin 7, type II; keratin 72; keratin 72, pseudogene; keratin 72, type II; keratin 8; keratin 8, type II; keratin 86; keratin complex 2, basic, gene 1; keratin complex 2, basic, gene 17; keratin complex 2, basic, gene 35; keratin complex 2, basic, gene 4; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin complex 2, basic, gene 7; keratin complex 2, basic, gene 8; keratin complex 2, gene 17; keratin complex 2, gene 6a; keratin IV; keratin K3; keratin K6; keratin K6h; keratin protein K6irs; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 2 epidermal; keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 59 kDa, component IV; keratin, type II cytoskeletal 60 kDa, component III; keratin, type II cytoskeletal 6A; keratin, type II cytoskeletal 6C; keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 72; keratin, type II cytoskeletal 8; Keratin, type II cytoskeletal cochleal; keratin-1; Keratin-2 epidermis; keratin-2e; Keratin-3; Keratin-4; keratin-5; keratin-6A; Keratin-6-alpha; keratin-6C; keratin-7; Keratin-72; keratin-8; KERIB; KO; Krt1; krt1 {ECO:0000250; KRT1A; Krt2; krt2 {ECO:0000250; Krt-2.1; Krt-2.4; Krt-2.8; Krt2-1; Krt2-17; Krt2-2; Krt2-35; Krt2-4; Krt2-5; Krt2-6; Krt2-6a; Krt2-6c; Krt2-7; KRT2-8; KRT2A; KRT2E; KRT3; KRT4; krt4 {ECO:0000250; Krt5; KRT5A; KRT6; Krt6a; KRT6C; KRT6D; KRT6IRS2; Krt7; krt7 {ECO:0000250; Krt72; Krt72-ps; Krt8; Krt86; KRTA; KRTE; LOC683313; LOW QUALITY PROTEIN: keratin, type II cytoskeletal 7; MGC116967; MGC116968; mK6[a]; MK6a; mK6-alpha; NEPPK; otokeratin; pan keratin; PC3; Sak57; sarcolectin; SCL; similar to keratin 7; similar to keratin complex 2, basic, gene 6a; Tfip8; tuftelin interacting protein 8
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 100049664, 100049665, 100152077, 100157304, 100157675, 100301161, 100345579, 100348388, 100348891, 100352658, 100353162, 100353415, 100353668, 100511564, 100626722, 102164968, 105866, 110308, 110310, 120093743, 140807, 16678, 16681, 16682, 16687, 16691, 25626, 281268, 281269, 300242, 300250, 315323, 369017, 3848, 3849, 3850, 3851, 3852, 3853, 3855, 3856, 395772, 406227, 406228, 407188, 407189, 407757, 407779, 408041, 426896, 51350, 527819, 531057, 535697, 614456, 768882, 769040, 77055, 786381
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov