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CZC 54252 hydrochloride, Tocris Bioscience™

Catalog Number 453410
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Quantity:
10 mg
50 mg
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1784253-05-9
czc 54252 hydrochloride, n-2-5-chloro-2-2-methoxy-4-morpholin-4-ylanilino pyrimidin-4-yl amino phenyl methanesulfonamide;hydrochloride, n-2-5-chloro-2-2-methoxy-4-4-morpholinyl phenyl amino-4-pyrimidinyl amino phenyl methanesulfonamide hydrochloride
44252734
CHEBI:78414
This item is not returnable. View return policy
1784253-05-9
czc 54252 hydrochloride, n-2-5-chloro-2-2-methoxy-4-morpholin-4-ylanilino pyrimidin-4-yl amino phenyl methanesulfonamide;hydrochloride, n-2-5-chloro-2-2-methoxy-4-4-morpholinyl phenyl amino-4-pyrimidinyl amino phenyl methanesulfonamide hydrochloride
44252734
CHEBI:78414

Potent LRRK2 inhibitor; neuroprotective

Potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM).
Molecular Formula C22H26Cl2N6O4S
Quantity 10 mg
InChI Key KWCBHUPLQMUKAF-UHFFFAOYSA-N
SMILES Cl.COC1=C(NC2=NC=C(Cl)C(NC3=CC=CC=C3NS(C)(=O)=O)=N2)C=CC(=C1)N1CCOCC1
IUPAC Name N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide hydrochloride
Molecular Weight (g/mol) 541.45
Formula Weight 541.45
Percent Purity >98%
Chemical Name or Material CZC 54252 hydrochloride
Recommended Storage Store at +4°C
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