Invitrogen™ DAZL Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5116570

Catalog No. PIPA5116570

Description

Positive Samples: Mouse testis, Rat testis Immunogen sequence: QRSYVVPPAY SAVNYHCNEV DPGAEVVPNE CSVHEATPPS GNGPQKKSVD R.

Protein expression pattern show that DAZL is involved in mitosis and meiosis of human germ cell. The DAZL gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females.The protein is expressed in germ cells of diverse mammalian species. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In humans, DAZL is expressed in primordial germ cells, adult testis, and the ovary. It plays a central role during spermatogenesis. Defects in DAZL may cause infertility due to severe oligozoospermia (az) and non obstructive azoospermia. The concentrations of DAZL transcripts were lower in men with spermatogenic failure. Drosophila and mouse mutants that have lost DAZ homologous gene function found to be azoospermic, just as with human azoospermia DAZ. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome.

Specifications

• Antigen: DAZL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DAZL
• Gene Alias: DAZ homolog; DAZH; DAZL; DAZL1; Dazla; Daz-like; DAZ-like autosomal; deleted in azoospermia like; deleted in azoospermia protein 3; deleted in azoospermia-like; Deleted in azoospermia-like 1; deleted in azoospermia-like protein; germline specific RNA binding protein; HGNC:2685; MGC26406; spermatogenesis gene on the Y-like autosomal; SPGYLA; SPGY-like-autosomal; testis secretory sperm-binding protein Li 204a; Tpx2; Tpx-2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13164, 1618, 680486
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.71 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q64368, Q92904
• Gene Symbols: DAZL
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 200-250 of human DAZL (NP_0013422).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov