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DCLK1 Mouse anti-Human, Clone: OTI1F8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526800

Catalog No. PIMA526800


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Description

Description

DCLK1 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK1 mRNA, like that of the homologous DCLK2 and DCLK3, is highly expressed in adult brain, but only DCLK1 and DCLK2 transcripts are present in human fetal brain and the developing mouse embryo, suggesting that DCLK1 and DCLK2 may play roles in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a gene that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. Unlike DCLK1, DCLK2 expression does not change in DCX-null mice.
Specifications

Specifications

DCLK1
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O15075
RP11-113P14.1, CL1, CLICK1, DCAMKL1, DCDC3A, DCLK; doublecortin and CaM kinase-like 1; doublecortin domain-containing protein 3A; doublecortin-like and CAM kinase-like 1; serine/threonine-protein kinase DCLK1
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
9201
Immunohistochemistry (Paraffin), Western Blot
OTI1F8
Unconjugated
DCLK1
Liquid
DCLK1
Human recombit protein fragment corresponding to amino acids 193-492 of DCLK1 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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