Tocris DDR1-IN-1 dihydrochloride
Selective DDR1 inhibitor
Manufacturer: Tocris 5077/10
DescriptionSelective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC50 values are 105 and 413nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.
- Chemical Name: N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride
- Formula: C30H31F3N4O3.2HCl
- Solubility: Soluble to 100mM in water and to 50mM in DMSO
- Purity: >98
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