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DDX58 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Supplier: Proteintech Group Inc 205661AP150UL
Description
The antibody is specific to DDX58.
Retinoic acid-inducible gene I, RIG-I is a pattern recognition receptor (PRR) involved in the recognition of viral dsRNA. Along with MDA5, RIG-I detects viral dsRNA and activates the innate immune response. Both MDA5 and RIG-I are RNA helicases and they perform overlapping as well as distinct roles. RIG-I is activated by dsRNAs without a 5′-triphosphate end and short dsRNAs, whereas MDA5 is activated by long dsRNAs. Once activated, both proteins signal through IPS-1 activating transcription factors NF-kappaB and IRF-3 (1) and ultimately activating apoptosis, cytokine signaling, and inflammation. RIG-I is essential for signaling by influenza A, influenza B, human respiratory syncytial virus (3), paromyxoviruses, Japanese encephalitis virus, and West Nile virus. MicroRNA-146a has been implicated in feedback inhibition of RIG-I-dependant antiviral response by negatively regulating RIG-I targets TRAF6, IRAK1, and IRAK2. Recent evidence has implicated RIG-I in the detection of cytosolic DNA through RNA polymerase III activity.Specifications
DDX58 | |
Polyclonal | |
Unconjugated | |
DDX58 | |
DDX58, DEAD box protein 58, RIG 1, RIG I, RIG-I | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
230073, 23586 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot | |
0.51 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
O95786, Q6Q899 | |
Ddx58 | |
Peptide | |
150 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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