RYBP Mouse anti-Canine, Human, Mouse, Non-human primate, Clone: OTI2B4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525946
DescriptionApoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD) death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. Several molecules including caspases and adaptor FADD contain DEDs. A novel protein that interacts with DED of caspase-8 and 10, and FADD was identified recently and designated DEDAF for DED associated factor. DEDAF is identical to the transcriptional repressor RYBP. DEDAF/RYBP is expressed in multiple tissues and cell lines. DEDAF interacts with FADD and augments the formation of CD95/FADD/capase-8 complexes at the cell membrane, and interacts with DED-containing DNA biding protein (DEDD) in the nucleus indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|AAP1, DEDAF, YEAF1; APAP-1; DED-associated factor; RING1 and YY1-binding protein; YY1 and E4TF1 associated factor 1; YY1 and E4TF1-associated factor 1; apoptin-associating protein 1; death effector domain-associated factor; ring1 interactor RYBP|
|-20° C, Avoid Freeze/Thaw Cycles|
|23429, 484690, 56353, 694390|
|Full length human recombit protein of RYBP produced in E.coli|
|Canine, Human, Mouse, Non-human primate|
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