DELE Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5144041

Catalog No. PIPA5144041

Description

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-Alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-Alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.

Specifications

• Antigen: DELE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Dele1
• Gene Alias: 0610009O20Rik; 2700004E22Rik; DAP3-binding cell death enhancer 1; Death ligand signal enhancer; Dele; Dele1; KIAA0141; RIKEN cDNA 0610009O20 gene
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9812
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Isotype: IgG

• Applications: ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4MG trehalose and 0.05MG sodium azide
• Gene Accession No.: Q14154
• Gene Symbols: Dele1
• Immunogen: E.coli-derived human KIAA0141/DELE1 recombinant protein (Position: E218-L430).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Lyophilized