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DERL1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549635

Catalog No. PA549635

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Predicted to react with bovine based on sequence homology.

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
Specifications

Specifications

DERL1
Polyclonal
PBS with 0.09% sodium azide
Q9BUN8, Q99J56
Derlin-1, Degradation in endoplasmic reticulum protein 1, DERtrin-1, Der1-like protein 1, DERL1, DER1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
67819, 79139
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
DERL1
Liquid
DERL1
KLH conjugated synthetic peptide between 224-251 amino acids from the C-terminal region of human DERL1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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