DERL2 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA549629
DescriptionFunctional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
|PBS with 0.09% sodium azide|
|Derlin-2, Degradation in endoplasmic reticulum protein 2, DERtrin-2, Der1-like protein 2, F-LAN-1, F-LANa, DERL2, DER2, FLANA|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|KLH conjugated synthetic peptide between 191-218 amino acids from the C-terminal region of human DERL2.|
|Antigen affinity chromatography|
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