DES Mouse anti-Human, Clone: OTI4G1, liquid, TrueMAB™ 

Mouse Monoclonal Antibody

Manufacturer:  OriGene TA502328

Catalog No. 50-167-3390

Description

Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predomitly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.

Specifications

• Antigen: DES
• Classification: Monoclonal
• Concentration: 0.63 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P17661
• Gene Alias: CDCD3, CMD1F, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 100 μL
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 1674

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI4G1
• Conjugate: Unconjugated
• Gene: DES
• Format: Liquid
• Gene Symbols: DES
• Immunogen: Human fragment corresponding to amino acids 104-391 of human DES produced in E.coli.
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human