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Desmoglein 2 Mouse anti-Human, Alexa Fluor® 488, Clone: CSTEM28, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$151.00 - $317.00

Specifications

Antigen Desmoglein 2
Clone CSTEM28
Target Species Human
Conjugate Alexa Fluor™ 488
Isotype IgG2b, kappa
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
53-915-982 Non-distribution product as customer accommodation. View Documents Invitrogen
53915982
100 μg Each for $317.00
Add to cart
 
53-915-980 Non-distribution product as customer accommodation. View Documents Invitrogen
53915980
25 μg Each for $151.00
Add to cart
 
Description

Description

This monoclonal antibody CSTEM28 reacts with human desmoglein 2 (DSG2), a type 1 transmembrane protein belonging to the cadherin family. DSG2 is expressed by epithelial cells, cardiomyocytes, endothelial progenitors, and CD34+CD45dim hematopoietic stem and progenitor cells. This adhesion molecule forms cell-cell adhesion complexes called desmosomes that provide tensile strength to tissues that experience mechanical stress. Other than its role in desmosome formation, DSG2 plays a role in barrier integrity, adhesion, migration, cell apoptosis, proliferation, vasculogenic mimicry, and intracellular signaling. DSG2-expressing endothelial progenitor cells are pro-angiogenic, suggesting a role in vasculature formation. On hematopoietic stem and progenitor cells, DSG2 expression is highest on CD38-CD90+ multi-potent cells. DSG2 expression is progressively decreased as a function of differentiation, with DSG2 expression absent on mature lymphocytes. DSG2 also serves as a receptor for adenoviruses and can be shed by mucosal barriers in the intestine. This CSTEM28 antibody has been tested by flow cytometric analysis of 2102ep cell line. This has also been tested by immunocytochemistry of fixed and permeabilized cells and can be used at less than or equal to 10 µg/mL. It is recommended the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 µm post-manufacturing filtered.

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
Specifications

Specifications

Desmoglein 2
Human
IgG2b, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
CSTEM28
Alexa Fluor™ 488
Flow Cytometry, Immunocytochemistry
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide
RUO

For Research Use Only

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