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Desmoglein-2 Antibody ([8E5), PE/Atto594, Novus Biologicals™
Mouse Monoclonal Antibody
Supplier: Novus Biologicals NBP254529PEATT594
Description
Desmoglein-2 Monoclonal specifically detects Desmoglein-2 in Human samples. It is validated for Flow Cytometry.Specifications
Desmoglein-2 | |
Monoclonal | |
PE/ATTO 594 | |
PBS with 0.05% Sodium Azide | |
DSG2 | |
Recombinant human Desmoglein-2 protein (Uniprot: Q14126) | |
0.1 mL | |
1829.0 | |
Human | |
IgG1 κ |
Flow Cytometry | |
[8E5] | |
Flow Cytometry | |
ARVC10, ARVD10, Cadherin family member 5, CDHF5MGC117034, CMD1BB, desmoglein 2, desmoglein-2, HDGC, MGC117036, MGC117037 | |
Mouse | |
Protein A or G purified | |
Primary | |
Recognizes a protein of 165kDa, identified as Desmoglein-2 (DSG2). This monoclonal antibody recognizes the extracellular domain of human desmoglein-2. Desmoglein-2 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Human Desmoglein-2 is a type I transmembrane glycoprotein of 1117 amino acid (aa) residues with a 23 aa signal peptide and a 25 aa propeptide. It differs from other classic cadherins by having four instead of five cadherin repeat domains in its extracellular region, and a much larger cyto | |
Store at 4°C in the dark. Do not freeze. |
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