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dGK Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 164591AP

Catalog No. 50-173-0958


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Description

Description

Mitochondrial deoxyguanosine kinase (DGUOK) is required for the phosphorylation of several deoxyribonucleosides and certain purine deoxykribonucleoside analogs widely employed as antiviral and chemotherapeutic agents. Purine deoxyribonucleoside analogs are extensively used in treatment of lymphoproliferative disorders. These compounds are administered as pro-drugs, and their efficiency is dependent on intracellular phosphorylation to the corresponding triphosphates. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predomitly by 2 deoxyribonucleoside kinases: cytosolic deoxycytidine kinase (DCK) and mitochondrial deoxyguanosine kinase (DGUOK also known as DGK). DGUOK expression is ubiquitous, with highest levels in muscle, brain, liver and lymphoid tissues. Defects in DGUOK are a cause of mitochondrial DNA depletion syndrome (MDS). MDS is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues.
Specifications

Specifications

dGK
0.23 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q16854, Q9QX60
deoxyguanosine kinase, dGK, DGUOK
Rabbit
IgG
150 μL
-20°C
Primary
1716, 27369, 297389
Immunoprecipitation
Unconjugated
DGUOK
Liquid
DGUOK
dGK Fusion Protein Ag9501
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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