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Dicer Mouse anti-Human, Clone: GT1176, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527827

Catalog No. PIMA527827


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Description

Description

Positive Control: A431 Predicted Reactivity: Mouse (97%), Zebrafish (93%), Xenopus laevis (92%), Pig (99%), Chicken (96%), Rhesus Monkey (100%), Bovine (99%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

DICER1 is a ribonuclease that has been extensively shown to be related to cancer. Small interfering RNAs are generated through DICER, and seem to play important roles in mitosis in normal cells and oncogenesis in mutated cells. DICER1 mutations are associated with blastoma, breast cancer, adenocarcinoma, and pancreatitis. In vision and hearing, DICER1 has been implicated in serious microRNA induced malformations of critical sensory cells. DICER1 is important in myelination and other nervous system protections. Finally, DICER1 is related to cardiovascular diseases, since microRNAs are aberrantly expressed in some pathological conditions.
Specifications

Specifications

Dicer
Monoclonal
1 mg/ml
PBS with no preservative
Q9UPY3
DCR1, DICER1, Dicer, HERNA, MNG1, dicer 1 ribonuclease III
Mouse
IgG1
100 μl
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
23405
Western Blot
GT1176
Unconjugated
DICER1
Liquid
DICER1
Recombit protein encompassing a sequence within the aa 819-1112 of Human Dicer. The exact sequence is proprietary.
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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