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Dicer Mouse anti-Mouse, Active Motif™ Non-distribution product as customer accommodation.

Mouse Recombinant Monoclonal Antibody

$98.40 - $465.85

Specifications

Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Antigen Dicer
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3766 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
91242
10 μg
Each for $98.40
Add to cart
 
50-199-3765 Non-distribution product as customer accommodation.
View Documents
Active MotifSupplier Diversity Partner
91241
100 μg
Each for $465.85
Add to cart
 
Description

Description

Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.
Specifications

Specifications

Monoclonal
Primary
Dicer
Unconjugated
SDS
Product Certifications
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