DICER1 Monoclonal Antibody (OTI1E11), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA801631

Catalog No. 50-167-8902

Description

DICER1 is a ribonuclease that has been extensively shown to be related to cancer. Small interfering RNAs are generated through DICER, and seem to play important roles in mitosis in normal cells and oncogenesis in mutated cells. DICER1 mutations are associated with blastoma, breast cancer, adenocarcinoma, and pancreatitis. In vision and hearing, DICER1 has been implicated in serious microRNA induced malformations of critical sensory cells. DICER1 is important in myelination and other nervous system protections. Finally, DICER1 is related to cardiovascular diseases, since microRNAs are aberrantly expressed in some pathological conditions.

Specifications

• Antigen: DICER1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9UPY3
• Gene Symbols: DICER1
• Immunogen: Human recombit protein fragment corresponding to amino acids 1666-1922 of human DICER1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin)
• Clone: OTI1E11
• Conjugate: Unconjugated
• Gene: DICER1
• Gene Alias: DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23405
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid