Alfa Aesar™ Diethyl cyanomethylphosphonate, 98+%

Manufacturer: Alfa Aesar™ A10218-36

Quantity 500g

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Catalog No. AAA1021836

    N/A

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    Chemical Identifiers

    CAS 2537-48-6
    Molecular Formula C6H12NO3P
    Formula Weight 177.14g/mol
    MDL Number MFCD00001893
    UN Number UN3278
    Beilstein 1772981
    Synonym Cyanomethylphosphonic acid diethyl ester; Diethyl phosphonoacetonitrile
    Chemical Name or Material Diethyl cyanomethylphosphonate

    Specifications

    Boiling Point 132° to 135°C (1.2mmHg)
    Flash Point >110°C (230°F)
    Quantity 500g
    CAS 2537-48-6
    Molecular Formula C6H12NO3P
    Formula Weight 177.14g/mol
    MDL Number MFCD00001893
    UN Number UN3278
    Beilstein 1772981
    Synonym Cyanomethylphosphonic acid diethyl ester; Diethyl phosphonoacetonitrile
    Health Hazard 1 Danger
    Health Hazard 2 GHS H Statement
    H331-H302-H312-H315-H319
    Toxic if inhaled.
    Harmful if swallowed.
    Harmful in contact with skin.
    Causes skin irritation.
    Causes serious eye irritation.
    Health Hazard 3 GHS P Statement
    P261-P280-P305+P351+P338-P304+P340-P405-P501a
    Avoid breathing dust/fume/gas/mist/vapors/spray.
    Wear protective gloves/protective clothing/eye protection/face protection.
    IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
    Continue rinsing.
    IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
    Store locked up.
    Dispose of contents/container in accordance with local/regional/national/international regulations.
    DOT Information Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: ORGANOPHOSPHORUS COMPOUND, LIQUID, TOXIC, N.O.S.
    Chemical Name or Material Diethyl cyanomethylphosphonate
    Assay ≥98%

    Description

    Applications
    Diethyl cyanomethyl phosphonate is used as an intermediate in Horner-Emmons reaction for the synthesis of substituted nitriles and their amide and heterocyclic derivatives. It is known as a modified Wittig reagent used in the preparation of alpha, beta-unsaturated nitriles from ketones or aldehydes like 3-hydroxy-3-methylbutanal. It reacts with epoxides and nitrones to prepare cyano-substituted cyclopropanes and aziridines respectively. It is actively involved in the synthesis of alpha-arylated alkanenitriles via reaction with aryl iodides in presence of CuI.

    Solubility
    Miscible with water, chloroform, terahydrofuran, ethyl acetate and methylene chloride.

    Notes
    Incompatible with acids, bases, oxidizing agents and reducing agents.

    GHS H Statement
    H331-H302-H312-H315-H319
    Toxic if inhaled.
    Harmful if swallowed.
    Harmful in contact with skin.
    Causes skin irritation.
    Causes serious eye irritation.

    GHS P Statement
    P261-P280-P305+P351+P338-P304+P340-P405-P501a
    Avoid breathing dust/fume/gas/mist/vapors/spray.
    Wear protective gloves/protective clothing/eye protection/face protection.
    IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.
    Continue rinsing.
    IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
    Store locked up.
    Dispose of contents/container in accordance with local/regional/national/international regulations.

    Danger

    SDS & Safety Documents

  • Description & Specifications
  • Safety and Handling

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