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Diethyl ethoxymethylenemalonate, 98+%, Thermo Scientific Chemicals
Description
Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatography (HPLC). It plays an important role in the Gould-Jacobs reaction to prepare quinolines. For example, anile reacts with this reagent to give 4-hydroxyquinoline. It acts as an intermediate in the production of flumequine, which is a fluoroquinolone antibiotic.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatography (HPLC). It plays an important role in the Gould-Jacobs reaction to prepare quinolines. For example, anile reacts with this reagent to give 4-hydroxyquinoline. It acts as an intermediate in the production of flumequine, which is a fluoroquinolone antibiotic.
Solubility
Miscible with chloroform, dichloromethane and methanol. Immiscible with water.
Notes
Incompatible with acids, bases, oxidizing agents and reducing agents.
Specifications
| Melting Point | -33°C |
| Density | 1.08 |
| Boiling Point | 136°C to 139°C (10 mmHg) |
| Flash Point | 144°C (291°F) |
| Odor | Ester-like |
| Refractive Index | 1.462 |
| Quantity | 50 g |
| Solubility Information | Miscible with chloroform,dichloromethane and methanol. Immiscible with water. |
| Formula Weight | 216.23 |
| Percent Purity | ≥98% |
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Safety and Handling
| Hazard Category | H302-H314-H317-H334-H335 |
| Hazard Statement | GHS H Statement H334-H315-H319-H317 May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. |
| Precautionary Statement | P260-P264b-P270-P271-P272-P280-P285-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P333+P313-P363-P501c |
| EINECSNumber | 201-725-7 |
| RTECSNumber | OO1100000 |
| TSCA | Yes |
| Recommended Storage | Ambient temperatures |
RUO – Research Use Only
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