DIO1 Mouse anti-Human, Clone: 1E4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524403
Peptide Sequence: DRVKRNILAM GEKTGMTRNP HFSHDNWIPT FFSTQYFWFV LKVRWQRLED TTELGGLAPN CPVVRLSGQR CNIWEFMQGN RPLVLNFGSC TThe protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3 ft.,5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3 ft. UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence.
|DIO1 (NP_000783.2, 35 a.a. ∽ 125 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.|
|PBS with no preservative; pH 7.4|
|DIO1; ITDI1; TXDI1|
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