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DNER Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5120373

Encompass

Catalog No. PIPA5120373


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Description

Description

Positive test controls include: Hela, HT-29, Mouse brain, Mouse eye, Mouse small intestine, Rat brain. The target is usually found in the following locations: Cell membrane, Single-pass type I membrane protein. Immunogen sequence: PATGWTESMA PRQLQPVPAT QEPDKILPRS QATVTLPTWQ PKTGQKVVEM KWDQVEVIPD IACGNASSNS SAGGRLVSFE VPQNTSVKIR QDATASLILL W

DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predominantly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

DNER
Polyclonal
Unconjugated
Dner
A930026D19Rik; BET; Brain EGF repeat-containing transmembrane protein; Bret; Delta and Notch-like epidermal growth factor-related receptor; delta/notch like EGF repeat containing; delta/notch-like EGF repeat containing; delta/notch-like EGF-related receptor; delta-notch-like EGF repeat-containing transmembrane; Dner; H_NH0150O02.1; LOW QUALITY PROTEIN: delta and Notch-like epidermal growth factor-related receptor; transmembrane protein Bet; UNQ26; UNQ262/PRO299; WUGSC:H_NH0150O02.1
Rabbit
Affinity Chromatography
RUO
227325, 316573, 92737
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Immunocytochemistry, Western Blot
0.56 mg/mL
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Q8JZM4, Q8NFT8
Dner
Recombinant fusion protein containing a sequence corresponding to amino acids 140-240 of human DNER (NP_620711.3).
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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