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DNMT3A dimethyl (Lys44) Rabbit anti-Human, Mouse, Unconjugated, Polyclonal, Active Motif™ Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

$116.85 - $356.95

Specifications

Monoclonal or Polyclonal Polyclonal
Primary or Secondary Primary
Antigen DNMT3A dimethyl (Lys44)
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-3331 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61324
10 μL
Each for $116.85
Add to cart
 
50-199-3330 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
61323
100 μL
Each for $356.95
Add to cart
 
Description

Description

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of Dnmt3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.
Specifications

Specifications

Polyclonal
Primary
DNMT3A dimethyl (Lys44)
Unconjugated
SDS
Product Certifications
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