Invitrogen™ DOCK2 Monoclonal Antibody (OTI4E12)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA526548

Catalog No. PIMA526548

Description

DOCK2 Monoclonal Antibody for IHC (P)

Dedicator of cytokinesis 2 (DOCK2) is a gene located on chromosome 5q15, encoding a member of the DOCK family of guanine nucleotide exchange factors (GEFs). DOCK2 plays a crucial role in the immune system by regulating the actin cytoskeleton, which is essential for cell movement and immune cell activation. It is predominantly expressed in hematopoietic cells, including lymphocytes and other leukocytes, where it facilitates chemotaxis and polarization by activating the small GTPase Rac. This activation is critical for processes such as lymphocyte homing, migration towards chemokines, and phagocytosis. Genetic mutations or dysregulation of DOCK2 can lead to immunodeficiency, characterized by impaired immune responses and increased susceptibility to infections. Research into DOCK2 focuses on its therapeutic potential in modulating immune responses and its role in disorders characterized by immune dysregulation, such as autoimmune diseases and chronic inflammation.

Specifications

• Antigen: DOCK2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q92608
• Gene Symbols: DOCK2
• Immunogen: Human recombinant protein fragment corresponding to amino acids 1544-1830 of DOCK2 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin)
• Clone: OTI4E12
• Conjugate: Unconjugated
• Gene: DOCK2
• Gene Alias: AI662014; AW122239; CED-5; dedicator of cytokinesis 2; dedicator of cyto-kinesis 2; dedicator of cytokinesis protein 2; DOCK2; FLJ46592; Hch; IMD40; KIAA0209; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 2; MBC; Protein Hch
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1794
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid