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DOCK3/MOCA Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 206831AP

Catalog No. 50-173-3035


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Description

Description

Dedicator of cytokinesis3 (DOCK3), also named as MOCA and PBP, is a ~180 kDa protein involved in signaling transduction. It is a potential guanine nucleotide exchange factor (GEF) which activate some small GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of Dock3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3beta (GSK-3beta) at the plasma membrane, thereby promoting axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS.
Specifications

Specifications

DOCK3/MOCA
0.49 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q8CIQ7, Q8IZD9
dedicator of cytokinesis 3, DOCK3, KIAA0299, MOCA, Modifier of cell adhesion, PBP, Presenilin binding protein
Rabbit
IgG
150 μL
-20°C
Primary
1795, 208869
Western Blot
Unconjugated
DOCK3
Liquid
DOCK3
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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