DOK2 Mouse anti-Canine, Human, Mouse, Non-human primate, Rat, Clone: OTI2D10, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525661
DescriptionDocking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. Dok-2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. Dok-2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the Dok1 and Dok2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the Dok proteins serve as mediators of bcr-abl signaling. The role of Dok proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9;22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|p56DOK, p56dok-2, docking protein 2, downstream of tyrosine kinase 2, p56dok-2|
|-20° C, Avoid Freeze/Thaw Cycles|
|13449, 290361, 486133, 706317, 9046|
|Full length human recombit protein of DOK2 produced in HEK293T cell|
|Canine, Human, Mouse, Non-human primate, Rat|
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