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DOK3 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549701

Catalog No. PA549701


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Description

Description

The antibody detects endogenous level of total DOK3 protein.

DOK3 gene maps to chromosome 5q35.3. Dok3 was tyrosine phosphorylated by Src family members Lck, Fyn, and Lyn. Immunoprecipitation studies showed that Dok3 bound inhibitors SHIP and Csk but did not bind RasGAP. Dok3 binding to SHIP occurred via the SH2 domain. Dok3 also bound Csk via the Csk SH2 domain with possible involvement of the Csk SH3 domain as well.DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function
Specifications

Specifications

DOK3
Polyclonal
Unconjugated
DOK3
Liquid
DOK3
Fusion protein corresponding to C terminal 300 amino acids of human docking protein 3
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
ELISA, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q7L591
docking protein 3, DOKL
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
79930
Documents
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