Invitrogen™ Doublecortin Recombinant Rabbit Monoclonal Antibody (BLR168J)

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA544521	Invitrogen™ MA544521	100 μL
PIMA544522	Invitrogen™ MA544522	10 μL

Description

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.

Specifications

• Antigen: Doublecortin
• Concentration: 50 μg/mL
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
• Gene Accession No.: O43602
• Gene ID (Entrez): 1641
• Immunogen: Peptide representing a region between residue 200 and 250 of Human Doublecortin.
• Product Type: Antibody

• Clone: BLR168J
• Content And Storage: 4°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: DCX
• Gene Alias: DBCN; Dbct; DC; Dcn; DCX; doublecortex; doublecortin; doublin; lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS
• Gene Symbols: DCX
• Primary or Secondary: Primary
• Purification Method: purified