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Human DR5, Synthetic Peptide, Invitrogen™

Synthetic Peptide

Manufacturer:  Invitrogen PEP0021

Catalog No. PEP0021


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Description

Description

DR5 Synthetic Peptide, PEP-0021, from Invitrogen.

DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome. This peptide corresponds to 20 amino acids near the carboxy terminus of human DR5.PEP-0021 can be used as a blocking peptide with polyclonal antibody PA5-19895.
Specifications

Specifications

Synthetic Peptide
purified
50μg
Blocking Assay, Control
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
Human
RUO
0.02% sodium azide
TNFRSF10B
Blocking Assay, Control
8795
Human
200μg/mL
Liquid
N
PBS
-20°C
Human DR5
O14763
Peptide
Documents
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