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DTX1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549658

Catalog No. PA549658

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Predicted to react with mouse based on sequence homology.

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1.
Specifications

Specifications

DTX1
Polyclonal
PBS with 0.09% sodium azide
Q86Y01
E3 ubiquitin-protein ligase DTX1, 632-, Protein deltex-1, Deltex1, hDTX1, DTX1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1840
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
DTX1
Liquid
DTX1
KLH conjugated synthetic peptide between 382-410 amino acids from the Central region of human DTX1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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