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DTX1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550494

Catalog No. PA550494


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Description

Description

The antibody detects endogenous levels of total DTX1 protein.

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1.
Specifications

Specifications

DTX1
Polyclonal
Unconjugated
DTX1
Liquid
DTX1
Synthetic peptide corresponding to a region derived from internal residues of human deltex homolog 1 (Drosophila)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin)
0.9 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q86Y01, Q61010
hDx-1
Rabbit
IgG
100 μL
-20°C
Primary
14357, 1840
Documents
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