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DUSP10 Mouse anti-Human, Clone: OTI2H1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526813

Catalog No. PIMA526813


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Description

Description

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.
Specifications

Specifications

DUSP10
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q9Y6W6
MKP-5, MKP5, dual specificity phosphatase MKP-5, dual specificity protein phosphatase 10, map kinase phosphatase 5, mitogen-activated protein kinase phosphatase 5, serine/threonine specific protein phosphatase
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
11221
Immunohistochemistry (Paraffin), Western Blot
OTI2H1
Unconjugated
DUSP10
Liquid
DUSP10
Human recombit protein fragment corresponding to amino acids 180-482 of DUSP10 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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