DUSP14 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5120080

Catalog No. PIPA5120080

Description

Positive test controls include: Hela, SW480, BT-474, SKOV3, Mouse kidney, Mouse brain. Immunogen sequence: MSSRGHSTLP RTLMAPRMIS EGDIGGIAQI TSSLFLGRGS VASNRHLLQA RGITCIVNAT IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV SRKHGATLVH CAAGVSRSAT LCIAYLMKFH NVCLLEAYNW VKARRPVIRP NVGFWRQLID YERQLFGKST VKMVQTPYGI VPDVYEKESR HLMPYWGI

In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.

Specifications

• Antigen: DUSP14
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: DUSP14
• Gene Alias: 1110014C10Rik; 2310042C07Rik; D11Ertd395e; dual specificity phosphatase 14; dual specificity protein phosphatase 14; DUSP14; MAP kinase phosphatase 6; MAP kinase phsophatase 6; mitogen-activated protein kinase phosphatase 6; Mkp-1 like protein tyrosine phosphatase; MKP-1-like protein tyrosine phosphatase; MKP6; MKP-6; MKP-L
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11072, 360580, 56405
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Western Blot
• Concentration: 1.11 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O95147, Q9JLY7
• Gene Symbols: DUSP14
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human DUSP14 (NP_008957.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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