DUX4 Mouse anti-Human, Mouse, Clone: P2B1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527584
DescriptionDUX4 (also known as Double homeobox 4) is the leading candidate causative gene for facioscapulohumeral dystrophy (FSHD), a degenerative skeletal muscle disease and one of the most common muscular dystrophies. FSHD is caused by the deletion of a subset of D4Z4 macrosatellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4. DUX4 expression is epigenetically suppressed in differentiated tissues and the residual DUX4 transcripts are spliced to remove the carboxyterminal domain that has been associated with cell toxicity. In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle, and possibly other differentiated tissues, and results in a small percentage of cells expressing relatively abundant amounts of the full-length DUX4 mRNA and protein.
|PBS with 50% glycerol and 0.09% sodium azide; pH 7.4|
|Double homeobox 4, Double homeobox 10, DUX10, Double homeobox protein 4/10, DUX4L, DUX4L1|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|C-terminal 76 amino acids of DUX4 with glutathione-s-transferase (gst) tag|
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