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DUX4 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548497

Catalog No. PA548497

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

DUX4 (also known as Double homeobox 4) is the leading candidate causative gene for facioscapulohumeral dystrophy (FSHD), a degenerative skeletal muscle disease and one of the most common muscular dystrophies. FSHD is caused by the deletion of a subset of D4Z4 macrosatellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4. DUX4 expression is epigenetically suppressed in differentiated tissues and the residual DUX4 transcripts are spliced to remove the carboxyterminal domain that has been associated with cell toxicity. In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle, and possibly other differentiated tissues, and results in a small percentage of cells expressing relatively abundant amounts of the full-length DUX4 mRNA and protein. [Snider et al. (2010) PLoS Genetics.6(10): e1001181]
Specifications

Specifications

DUX4
Polyclonal
PBS with 0.09% sodium azide
Q9UBX2
Double homeobox protein 4, Double homeobox protein 10 {ECO:0000312|EMBL:AAK915091}, DUX4 (HGNC:50800), DUX10
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
100288687
Western Blot
Unconjugated
DUX4
Liquid
DUX4
KLH conjugated synthetic peptide between 376-404 amino acids from the C-terminal region of human DUX4.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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