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Invitrogen™ Dynabeads™ SARS-CoV-2 Spike
The Dynabeads™ SARS-CoV-2 Spike consists of superparamagnetic beads coupled with a trimeric spike protein. The spike protein is a patented recombinant trimeric structure combining the S1 subunit, including the receptor binding domain (RBD), and the S2 subunit found on the surface of the SARS-CoV-2 virus.
$350.00 - $1446.00
Specifications
| Certifications/Compliance | ISO 13485 |
|---|---|
| Concentration | 1 mg/mL |
| Content And Storage | The beads are supplied in 0.05 M Tris-buffered saline (TBS) with 0.001% Tween-20 and 0.02% NaN3. Store at 2–8°C. |
| Detection Method | Absorbance at 450 nm |
| Color | Brown beads in colorless suspension |
| Catalog Number | Mfr. No. | Volume (Metric) | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Volume (Metric) | Price | Quantity & Availability | |||||
18100D
|
Invitrogen™
18100D |
3 mL |
Each for $350.00
|
|
18100DFIVE
|
Invitrogen™
18100DFIVE |
5 x 3 mL |
Each for $1,446.00
|
|
Description
- Dynabeads SARS-CoV-2 Spike consists of superparamagnetic beads coupled with a trimeric spike protein
- The spike protein is a patented recombinant trimeric structure combining the S1 subunit, including the receptor binding domain (RBD), and the S2 subunit found on the surface of the SARS-CoV-2 virus
- Virus spike protein binds to human host cells via the angiotensin-converting enzyme 2 (ACE2) receptor to initiate virus attachment, as well as to antibodies produced in the body as a response to SARS-CoV-2 infection
- This Dynabeads SARS-CoV-2 Spike is also included in enzyme‐linked immunosorbent assay (ELISA) kits designed to detect and quantify the level of human SARS-CoV-2 IgG, IgM, and Total Ig antibodies from serum and plasma samples
- Kits can be used manually with a DynaMag-96 magnet or in an automated fashion using a KingFisher instrument
- Magnetic beads significantly improve the binding kinetics to cut the ELISA incubation time in half (45 minutes) compared to the more conventional plate-based ELISAs (90 minutes)
- Since the spike protein binds host cells to initiate the entrance of SARS-CoV-2 virus into the epithelial cells of the lungs via ACE2, the beads may also be used for isolation of ACE2+ cells or for ACE2 protein purification
- Dynabeads-facilitated automation limits hands-on time
- Also available in SARS-CoV-2 ELISA kits
- For research use only, not for use in diagnostic procedures
Specifications
| ISO 13485 | |
| The beads are supplied in 0.05 M Tris-buffered saline (TBS) with 0.001% Tween-20 and 0.02% NaN3. Store at 2–8°C. |
|
| Brown beads in colorless suspension | |
| Monosized, superparamagnetic polystyrene magnetic beads | |
| KingFisher™ Flex or Apex Instruments, DynaMag™-96 Side Skirted, Magnetic 96-Well Separator, ELISA Plate Reader (450 nm) | |
| Dynabeads™ magnetic beads | |
| 2.7 μm |
| 1 mg/mL | |
| Absorbance at 450 nm | |
| Binding of human antibodies towards SARS-CoV-2 (Spike trimer) | |
| Dynabeads™ magnetic beads coated with trimeric SARS-CoV-2 spike protein | |
| Yes, on KingFisher™ Flex or Apex instruments | |
| Wet ice (2° to 8°C) |
For research use only. Not for use in diagnostic procedures.
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