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Dynein Mouse anti-Bovine, Drosophila, Human, Mouse, Ovine, Porcine, Rat, Xenopus laevis, Clone: 74.1, eBioscience™ Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  LIFE TECHNOLOGIES 14977280

Encompass

Catalog No. 14-977-280


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Description

Description

The monoclonal antibody 74.1 recognizes all known forms of the 74 kDa intermediate chain subunit of mammalian cytoplasmic dynein. Cytoplasmic dynein is a microtubule-stimulated ATPase responsible for movement of membrane-bound organelles in a directed manner toward the minus end of microtubules, commonly found at the centrosome. Dynein is responsible for the transport of lysosomes, endosomes, phagosomes, peroxisomes, mitochondria, and vesicles from the endoplasmic reticulum destined for the Golgi. During mitosis, dynein is responsible for positioning the spindle apparatus as well as being localized to the kinetochores to facilitate chromosome movement.The 74.1 antibody recognizes human, mouse, rat, bovine, sheep, Xenopus, porcine, and Drosophila dynein intermediate chain. This 74.1 antibody has been tested by immunocytochemistry of methanol-fixed and permeabilized cells and can be used at less than or equal to 1 µg/mL. This 74.1 antibody has been tested by western blot of reduced and non-reduced HeLa cell lysate and can be used at less than or equal to 5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

Dynein Monoclonal antibody specifically detects Dynein in Bovine, Drosophila, Human, Mouse, Ovine, Porcine, Rat, Xenopus laevis samples. It is validated for ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Specifications

Specifications

Dynein
Monoclonal
0.5 mg/mL
PBS with 0.09% Sodium Azide; pH 7.2
P61285, P63167, P63168, P63170, Q3MHR3, Q78P75, Q96FJ2, Q9D0M5
Mouse
25 μg
Primary
Bovine, Drosophila, Human, Mouse, Ovine, Porcine, Rat, Xenopus laevis
Liquid
ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
74.1
Unconjugated
DYNLL2
1700064A15Rik; 6720463E02Rik; 8 kDa dynein light chain; 8 kDa dynein light chain b; 8kD LC; 8kDa LC; 8kDLC; C87222; CDLC2; cytoplasmic dynein light polypeptide; cytoplasmic dynein light polypeptide 1; cytoplasmic light-chain dynein; cytosolic DH IC-1; DLC1; Dlc2; Dlc8; DLC8b; DNCL1; DNCL1B; DNCLC1; dynein LC8; dynein light chain 1, cytoplasmic; Dynein light chain 2, cytoplasmic; dynein light chain LC8-type 1; Dynein light chain LC8-type 2; dynein light chain-2; dynein, cytoplasmic, light chain 1; dynein, cytoplasmic, light peptide; dynein, cytoplasmic, light polypeptide 1; dynein, light chain, LC8-type 1; dynein, light chain, LC8-type 2; Dynll1; Dynll2; hdlc1; LC8; LC8; PIN; LC8a; LOC540369 protein; mPIN; Pin; Protein inhibitor of neuronal nitric oxide synthase; protein inhibitor of nitric oxide synthase; radial spoke 22 homolog; RSPH22; similar to cytoplasmic dynein light chain 1
Affinity chromatography
RUO
100157773, 100512860, 101118902, 101121274, 140734, 140735, 404151, 540369, 56455, 58945, 68097, 8655
Antibody
IgG2b κ
Safety and Handling

Safety and Handling

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