DYRK2 Mouse anti-Human, Clone: OTI1G8, lyophilized, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene CF810286
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCODYRK2, or dual specificity tyrosine-phosphorylation-regulated kinase 2, has a role in the regulation of cellular growth and/or development. In response to DNA damage, DYRK2 regulates p53 phosphorylation on Ser-46 to induce apoptosis. DYRK2 has been proposed to inactivate GYS1 by phosphorylation at Ser-641, and potentially a second phosphorylation site, thus regulating glycogen synthesis. DYRK2 also phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
|Human recombit protein fragment corresponding to amino acids 1-210 of human DYRK2 produced in E.coli.|
|PBS with 8% trehalose and no preservative; pH 7.3|
|dual specificity tyrosine phosphorylation regulated kinase 2|
|-20° C, Avoid Freeze/Thaw Cycles|
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