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DYRK2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548658

Catalog No. PA548658

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

DYRK2, or dual specificity tyrosine-phosphorylation-regulated kinase 2, has a role in the regulation of cellular growth and/or development. In response to DNA damage, DYRK2 regulates p53 phosphorylation on Ser-46 to induce apoptosis. DYRK2 has been proposed to inactivate GYS1 by phosphorylation at Ser-641, and potentially a second phosphorylation site, thus regulating glycogen synthesis. DYRK2 also phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
Specifications

Specifications

Dyrk2
Polyclonal
PBS with 0.09% sodium azide
Q92630, Q5U4C9
Dual specificity tyrosine-phosphorylation-regulated kinase 2, Dyrk2
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
69181, 8445
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
DYRK2
Liquid
DYRK2
KLH conjugated synthetic peptide between 521-549 amino acids from the C-terminal region of mouse Dyrk2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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