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Dysferlin Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551347

Catalog No. PA551347


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Description

Description

The antibody detects endogenous levels of total Dysferlin protein.

The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants.
Specifications

Specifications

Dysferlin
Polyclonal
Unconjugated
DYSF
Liquid
DYSF
Synthetic peptide of human DYSF
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin)
1.8 mg/mL
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
O75923, Q9ESD7
FER1L1, FLJ00175, FLJ90168, LGMD2B
Rabbit
IgG
100 μL
-20°C
Primary
26903, 8291
Documents
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