E-Cadherin Mouse anti-Human, Mouse, Biotin, Clone: CDH1/1121 + CDH1/1122, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP247829B
DescriptionE-Cadherin Monoclonal antibody specifically detects E-Cadherin in Human, Mouse samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence.
|CDH1/1121 + CDH1/1122|
|Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence|
|Recombinant fragment (119 Amino acid residues around aa 400-500) of human E-Cadherin protein|
|Protein A or G purified|
|Cancer, Cell Cycle and Replication, Cellular Markers, Extracellular Matrix, Phospho Specific, Plasma Membrane Markers, Signal Transduction|
|Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% Sodium Azide|
|Arc-1, cadherin 1, E-cadherin (epithelial), cadherin 1, type 1, E-cadherin (epithelial), cadherin-1, calcium-dependent adhesion protein, epithelial, CAM 120/80, CD324, CD324 antigen, CDHE, cell-CAM 120/80, ECAD, E-cadherin, Epithelial cadherin, LCAM, UVOE-Cadherin, uvomorulin|
|Store at 4C in the dark.|
|Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.|
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