E2F3 Monoclonal Antibody (3E2F04 (PG37)), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA511319

Catalog No. PIMA511319

Description

MA5-11319 targets E2F-3 Transcription Factor in GS and IF applications and shows reactivity with Human samples. The MA5-11319 immunogen is recombinant human E2F-3 protein.

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.

Specifications

• Antigen: E2F3
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: O00716
• Gene Symbols: E2F3
• Immunogen: Recombinant human E2F-3 protein
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ChIP Assay, Gel Shift, Western Blot
• Clone: 3E2F04 (PG37)
• Conjugate: Unconjugated
• Gene: E2F3
• Gene Alias: DKFZp686C18211; E2F transcription factor 3; E2f3; E2F-3; E2f3a; E2F3b; KIAA0075; MGC104598; RGD1561600; RP1-177P22.2; Transcription factor E2F3
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1871
• Content And Storage: 4° C
• Form: Liquid