E2F3 Monoclonal Antibody (PG30), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA125333

Catalog No. PIMA125333

Description

MA1-25333 detects E2F3 from human samples. MA1-25333 has been successfully used in immunoprecipitation, gel shift and Western blot procedures. The MA1-25333 immunogen is recombit human protein. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.

Specifications

• Antigen: E2F3
• Classification: Monoclonal
• Concentration: 2 mg/mL
• Gene: E2F3
• Gene Alias: RP1-177P22.2, DKFZp686C18211, E2F-3, KIAA0075, MGC104598
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1871
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Gel Shift, Immunoprecipitation, Western Blot
• Clone: PG30
• Conjugate: Unconjugated
• Gene Accession No.: O00716
• Gene Symbols: E2F3
• Immunogen: Recombit human protein.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a