E2F3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA595394

Catalog No. PIPA595394

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL.

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner.

Specifications

• Antigen: E2F3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: E2F3
• Gene Alias: DKFZp686C18211, E2F transcription factor 3, E2f3, E2F-3, E2f3a, E2F3b, KIAA0075, MGC104598, RGD1561600, RP1-177P22.2, Transcription factor E2F3
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13557, 1871, 291105
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4MG trehalose and no preservative
• Gene Accession No.: O00716, O35261
• Gene Symbols: E2F3
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human E2F3 (278-320aa QSCTLDLKLLTEDSENQRLAYVTYQDIRKISGLKDQTVIVVKA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG