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E6AP, Polyclonal, Bethyl Laboratories Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Bethyl Laboratories, IncSupplier Diversity Partner A300351AM

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Catalog No. 50-155-7436


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt.

UBE3A interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53 tumor-suppressor protein for ubiquitin-mediated proteolysis. It is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and efficiently promotes its own degradation in vivo. It appears that only unmodified E6-AP molecules can bind efficiently to p53 in the presence of the HPV E6 oncoprotein. UBE3A binds UBQLN1 and UBQLN2. Defects in UBE3A are a cause of Angelman syndrome (AS) [MIM:105830]; also known as  ft.happy puppet syndrome ft.. AS is characterized by features of severe motor and intellectual retardation, microcephaly, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, hyperactivity, hypopigmentation, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, and an unusual facies characterized by macrostomia, a large mandible and open-mouthed expression, a great propensity for protruding the tongue ( ft.tongue thrusting ft.), and an occipital groove. UBE3A contains 1 HECT-type E3 ubiquitin-protein ligase domain.
Specifications

Specifications

E6AP
Polyclonal
TBS with 0.1% BSA and 0.09% sodium azide
O08759, Q05086
ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A
Rabbit
IgG
100 μl
4° C
Primary
22215, 7337
Western Blot
Unconjugated
UBE3A
liquid
UBE3A
Between 75 and 125
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
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