EAPP Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 169311AP
DescriptionThis protein may play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The C-terminal of EAPP binds the N-terminal of E2F1 and also interacts with E2F2 and E2F3, but not E2F4.
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|BM036, C14orf11, E2F associated phosphoprotein, EAPP|
|299043, 55837, 66266|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|EAPP Fusion Protein Ag10403|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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