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EAR2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549785

Catalog No. PA549785


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Description

Description

The antibody detects endogenous levels of total EAR2 / NR2F6 protein.

Transcription factor predomitly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5 ft.-AGGTCA-3 ft. direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintece of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
Specifications

Specifications

EAR2
Polyclonal
Unconjugated
NR2F6
Liquid
NR2F6
Synthesized peptide derived from N-terminal of human NR2F6.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P10588, P43136, O09017
EAR-2, EAR2, ERBAL2
Rabbit
IgG
100 μL
-20°C
Primary
13864, 2063, 245980
Documents
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